May 04, 2019 I had a fight with a Kreml in my Izumo at 9-10km. First salvo 1 pen,some bounce, 0dmg. Second salvo 3 pen,some bounce,0 dmg? Is this a joke or bug or hands of Stalin or what? 4 pens with no dmg? Thats ridiculous. Sep 27, 2016 As someone that shoots a lot of HE at tier 9 BBs I would say the Iowa is much more vulnerable to HE than the Izumo because it has all the superstructure. For whatever reason I get lots of 0 dmg hits on that thing while Iowas get ripped to shreds by 130mm HE.
IZUMO1
Available structures
PDB
Ortholog search:
List of PDB id codes
5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E
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Identifiers
Aliases
IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1
External IDs
Gene location (Human)
Chr.
Chromosome 19 (human)[1]
Band
19q13.33
Start
48,740,852 bp[1]
End
48,746,909 bp[1]
Gene location (Mouse)
Chr.
Chromosome 7 (mouse)[2]
Band
7|7 B3
Start
45,621,811 bp[2]
End
45,628,823 bp[2]
Gene ontology
Molecular function
•receptor binding •protein homodimerization activity •GO:0001948 protein binding •identical protein binding •protein binding involved in heterotypic cell-cell adhesion
•cell adhesion •sperm-egg recognition •single fertilization •fusion of sperm to egg plasma membrane involved in single fertilization •heterotypic cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
NM_182575 NM_001321864 NM_001321865
RefSeq (protein)
NP_001308793 NP_001308794 NP_872381
(or, your previous install if you’re upgrading)g)At the Chimera Boot Screen, choose your new “OSX” installation. Mac os x yosemite dmg file download. Close “Disk Utility”.f)You’ll be asked the location to install. Choose “OSX”.
Location (UCSC)
Chr 19: 48.74 – 48.75 Mb
Chr 7: 45.62 – 45.63 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene.[5] In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes. [6]
0 Dmg Pens On Izumo People
Function[edit]
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.[7]
0 Dmg Pens On Izumo Air
Studies have shown that male Izumo knockout mice are sterile because their sperm are unable to fuse to the oocyte membrane.[1] Izumo -/- mice produced morphologically normal sperm that were able to penetrate the zona pellucida, but could not fuse with to the eggs. In fact, it is necessary to relocate the IZUMO1 to the site of oocyte fusion [8]. In-vitro human experiments have also been conducted, suggesting that Izumo is required for human gamete fusion. [1]
0 Dmg Pens On Izumo Head
Through the use of Western Blot analyses, it has been shown that Izumo is only expressed in the testis and is found on mature spermatozoa. [9] Izumo-1 located on mature spermatozoa that have undergone capacitation binds to its receptor Juno, which is located on the oolemma of eggs. [10]
References[edit]
^ abcGRCh38: Ensembl release 89: ENSG00000182264 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000064158 - Ensembl, May 2017
^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
^'Entrez Gene: Izumo sperm-egg fusion 1'.
^ Bianchi, Enrica, et al. 'Juno is the egg Izumo receptor and is essential for mammalian fertilization.' Nature 508.7497 (2014): 483.
^Inoue N, Ikawa M, Isotani A, Okabe M (2005). 'The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs'. Nature. 434 (7030): 234–8. Bibcode:2005Natur.434.234I. doi:10.1038/nature03362. PMID15759005.
^Ikawa, M., Inoue, N., Benham, A. M., & Okabe, M. (2010). Fertilization: a sperm's journey to and interaction with the oocyte. The Journal of clinical investigation, 120(4), 984-94.
^ Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Molecular reproduction and development. 2009;76(12):1188-1199.
^ Bianchi E, Doe B, Goulding D, Sanger Mouse Genetics Project, Wright GJ. Juno is the egg Izumo receptor and is essential for mammalian fertilisation. Nature. 2014;508(7497):483-487.
0 Dmg Pens On Izumo Cars
Further reading[edit]
Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L (2013). 'Novel locus including FGF21 is associated with dietary macronutrient intake'. Human Molecular Genetics. 22 (9): 1895–902. doi:10.1093/hmg/ddt032. PMC3612009. PMID23372041.
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006). 'Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization'. Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID17047026.
Granados-Gonzalez V, Aknin-Seifer I, Touraine RL, Chouteau J, Wolf JP, Levy R (2008). 'Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure'. Fertility and Sterility. 90 (4): 1246–8. doi:10.1016/j.fertnstert.2007.09.008. PMID18082733.
Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P (2009). 'Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm'. Molecular Reproduction and Development. 76 (12): 1188–99. doi:10.1002/mrd.21092. PMC3779078. PMID19658160.
Grayson P, Civetta A (2012). 'Positive Selection and the Evolution of izumo Genes in Mammals'. International Journal of Evolutionary Biology. 2012: 958164. doi:10.1155/2012/958164. PMC3432370. PMID22957301.
Inoue N, Ikawa M, Okabe M (2008). 'Putative sperm fusion protein IZUMO and the role of N-glycosylation'. Biochemical and Biophysical Research Communications. 377 (3): 910–4. doi:10.1016/j.bbrc.2008.10.073. PMID18952059.
0 Dmg Pens On Izumo X
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
0 Dmg Pens On Izumo E
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